All-trans-retinal Is a Closed-state Inhibitor of Rod Cyclic Nucleotide–gated Ion Channels

Rod vision begins when 11-cis-retinal absorbs a photon and isomerizes to all-trans-retinal (ATR) within the photopigment, rhodopsin. Photoactivated rhodopsin triggers an enzyme cascade that lowers the concentration of cGMP, thereby closing cyclic nucleotide–gated (CNG) ion channels. After isomerizat...

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Detalles Bibliográficos
Autores principales: McCabe, Sarah L., Pelosi, Diana M., Tetreault, Michelle, Miri, Andrew, Nguitragool, Wang, Kovithvathanaphong, Pranisa, Mahajan, Rahul, Zimmerman, Anita L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234497/
https://www.ncbi.nlm.nih.gov/pubmed/15078915
http://dx.doi.org/10.1085/jgp.200409011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234497/
https://www.ncbi.nlm.nih.gov/pubmed/15078915
http://dx.doi.org/10.1085/jgp.200409011

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