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Modulation of the Voltage Sensor of L-type Ca(2+) Channels by Intracellular Ca(2+)
Both intracellular calcium and transmembrane voltage cause inactivation, or spontaneous closure, of L-type (CaV1.2) calcium channels. Here we show that long-lasting elevations of intracellular calcium to the concentrations that are expected to be near an open channel (≥100 μM) completely and reversi...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234499/ https://www.ncbi.nlm.nih.gov/pubmed/15111645 http://dx.doi.org/10.1085/jgp.200308876 |