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A Gastropod Toxin Selectively Slows Early Transitions in the Shaker K Channel's Activation Pathway
A toxin from a marine gastropod's defensive mucus, a disulfide-linked dimer of 6-bromo-2-mercaptotryptamine (BrMT), was found to inhibit voltage-gated potassium channels by a novel mechanism. Voltage-clamp experiments with Shaker K channels reveal that externally applied BrMT slows channel open...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234574/ https://www.ncbi.nlm.nih.gov/pubmed/15148327 http://dx.doi.org/10.1085/jgp.200409047 |