A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo

BACKGROUND: Integrins are important adhesion molecules that regulate tumor and endothelial cell survival, proliferation and migration. The integrin α5β1 has been shown to play a critical role during angiogenesis. An inhibitor of this integrin, volociximab (M200), inhibits endothelial cell growth and...

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Detalles Bibliográficos
Autores principales: Bhaskar, Vinay, Zhang, Dong, Fox, Melvin, Seto, Pui, Wong, Melanie HL, Wales, Pauline E, Powers, David, Chao, Debra T, DuBridge, Robert B, Ramakrishnan, Vanitha
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235829/
https://www.ncbi.nlm.nih.gov/pubmed/18042290
http://dx.doi.org/10.1186/1479-5876-5-61

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235829/
https://www.ncbi.nlm.nih.gov/pubmed/18042290
http://dx.doi.org/10.1186/1479-5876-5-61

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