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A function blocking anti-mouse integrin α5β1 antibody inhibits angiogenesis and impedes tumor growth in vivo

BACKGROUND: Integrins are important adhesion molecules that regulate tumor and endothelial cell survival, proliferation and migration. The integrin α5β1 has been shown to play a critical role during angiogenesis. An inhibitor of this integrin, volociximab (M200), inhibits endothelial cell growth and...

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Detalles Bibliográficos
Autores principales:	Bhaskar, Vinay, Zhang, Dong, Fox, Melvin, Seto, Pui, Wong, Melanie HL, Wales, Pauline E, Powers, David, Chao, Debra T, DuBridge, Robert B, Ramakrishnan, Vanitha
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2235829/ https://www.ncbi.nlm.nih.gov/pubmed/18042290 http://dx.doi.org/10.1186/1479-5876-5-61

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