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Knorr-Rabe partial reduction of pyrroles: Application to the synthesis of indolizidine alkaloids
BACKGROUND: The Birch reduction of electron rich pyrroles does not occur readily. However, dissolving metal reduction with zinc under acidic conditions gives 3-pyrrolines (2,5-dihydropyrroles) in reasonable yield. This dissolving metal reduction was first reported by Knorr and Rabe in 1901 but since...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238744/ https://www.ncbi.nlm.nih.gov/pubmed/18197983 http://dx.doi.org/10.1186/1860-5397-4-3 |