R(2)(2)(8) motifs in Aminopyrimidine sulfonate/carboxylate interactions: Crystal structures of pyrimethaminium benzenesulfonate monohydrate (2:2:1) and 2-amino-4,6-dimethylpyrimidinium sulfosalicylate dihydrate (4:2:2)

BACKGROUND: Pyrimethamine [2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine] is an antifolate drug used in anti-malarial chemotherapy. Pyrimidine and aminopyrimidine derivatives are biologically important compounds owing to their natural occurrence as components of nucleic acids. RESULTS: In the cry...

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Detalles Bibliográficos
Autores principales: Balasubramani, Kasthuri, Muthiah, Packianathan Thomas, Lynch, Daniel E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238812/
https://www.ncbi.nlm.nih.gov/pubmed/17999751
http://dx.doi.org/10.1186/1752-153X-1-28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238812/
https://www.ncbi.nlm.nih.gov/pubmed/17999751
http://dx.doi.org/10.1186/1752-153X-1-28

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