Cargando…
The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells
BACKGROUND: The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding of newly synthesized secretory proteins such as insulin. Perturbations to ER homeostasis cause ER stress and subsequently activate cell signaling pathways, collectively known as the Unfolded Protein...
| Autores principales: | , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241665/ https://www.ncbi.nlm.nih.gov/pubmed/18286202 http://dx.doi.org/10.1371/journal.pone.0001648 |