Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I

The TOPRIM DXDXXG residues of type IA and II topoisomerases are involved in Mg(II) binding and the cleavage-rejoining of DNA. Mutation of the strictly conserved glycine to serine in Yersinia pestis and Escherichia coli topoisomerase I results in bacterial cell killing due to inhibition of DNA religa...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Bokun, Sorokin, Elena P., Tse-Dinh, Yuk-Ching
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241903/
https://www.ncbi.nlm.nih.gov/pubmed/18096618
http://dx.doi.org/10.1093/nar/gkm1126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241903/
https://www.ncbi.nlm.nih.gov/pubmed/18096618
http://dx.doi.org/10.1093/nar/gkm1126

Ejemplares similares