Oxidation of single-stranded oligonucleotides by carbonate radical anions: generating intrastrand cross-links between guanine and thymine bases separated by cytosines

The carbonate radical anion is a biologically important one-electron oxidant that can directly abstract an electron from guanine, the most easily oxidizable DNA base. Oxidation of the 5′-d(CCTACGCTACC) sequence by photochemically generated CO(3)(·−) radicals in low steady-state concentrations releva...

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Detalles Bibliográficos
Autores principales: Crean, Conor, Uvaydov, Yuriy, Geacintov, Nicholas E., Shafirovich, Vladimir
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241916/
https://www.ncbi.nlm.nih.gov/pubmed/18084033
http://dx.doi.org/10.1093/nar/gkm1092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241916/
https://www.ncbi.nlm.nih.gov/pubmed/18084033
http://dx.doi.org/10.1093/nar/gkm1092

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