AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP

Azidothymidine (AZT, zidovudine) is one of the few nucleoside inhibitors known to inhibit foamy virus replication. We have shown previously that up to four mutations in the reverse transcriptase gene of simian foamy virus from macaque (SFVmac) are necessary to confer high resistance against AZT. To...

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Detalles Bibliográficos
Autores principales: Hartl, Maximilian J., Kretzschmar, Benedikt, Frohn, Anne, Nowrouzi, Ali, Rethwilm, Axel, Wöhrl, Birgitta M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241919/
https://www.ncbi.nlm.nih.gov/pubmed/18096624
http://dx.doi.org/10.1093/nar/gkm1087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241919/
https://www.ncbi.nlm.nih.gov/pubmed/18096624
http://dx.doi.org/10.1093/nar/gkm1087

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