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AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP
Azidothymidine (AZT, zidovudine) is one of the few nucleoside inhibitors known to inhibit foamy virus replication. We have shown previously that up to four mutations in the reverse transcriptase gene of simian foamy virus from macaque (SFVmac) are necessary to confer high resistance against AZT. To...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241919/ https://www.ncbi.nlm.nih.gov/pubmed/18096624 http://dx.doi.org/10.1093/nar/gkm1087 |