Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling

BACKGROUND: O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of No...

Descripción completa

Detalles Bibliográficos
Autores principales: Okajima, Tetsuya, Reddy, BVVG, Matsuda, Tsukasa, Irvine, Kenneth D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242781/
https://www.ncbi.nlm.nih.gov/pubmed/18194540
http://dx.doi.org/10.1186/1741-7007-6-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242781/
https://www.ncbi.nlm.nih.gov/pubmed/18194540
http://dx.doi.org/10.1186/1741-7007-6-1

Ejemplares similares