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Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
BACKGROUND: O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of No...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242781/ https://www.ncbi.nlm.nih.gov/pubmed/18194540 http://dx.doi.org/10.1186/1741-7007-6-1 |