Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy

High activity of histone deacetylases (HDACs) causes epigenetic alterations associated with malignant cell behaviour. Consequently, HDAC inhibitors have entered late-phase clinical trials as new antineoplastic drugs. However, little is known about expression and function of specific HDAC isoforms in...

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Detalles Bibliográficos
Autores principales: Weichert, W, Röske, A, Gekeler, V, Beckers, T, Stephan, C, Jung, K, Fritzsche, F R, Niesporek, S, Denkert, C, Dietel, M, Kristiansen, G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243142/
https://www.ncbi.nlm.nih.gov/pubmed/18212746
http://dx.doi.org/10.1038/sj.bjc.6604199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243142/
https://www.ncbi.nlm.nih.gov/pubmed/18212746
http://dx.doi.org/10.1038/sj.bjc.6604199

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