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Peptide ligand screening of α-synuclein aggregation modulators by in silico panning

BACKGROUND: α-Synuclein is a Parkinson's-disease-related protein. It forms aggregates in vivo, and these aggregates cause cell cytotoxicity. Aggregation inhibitors are expected to reduce α-synuclein cytotoxicity, and an aggregation accelerator has recently been reported to reduce α-synuclein cy...

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Detalles Bibliográficos
Autores principales: Abe, Koichi, Kobayashi, Natsuki, Sode, Koji, Ikebukuro, Kazunori
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2244645/
https://www.ncbi.nlm.nih.gov/pubmed/18005454
http://dx.doi.org/10.1186/1471-2105-8-451

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