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Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

BACKGROUND: The complement system is thought to be involved in the pathogenesis of numerous neurological diseases. We previously reported that pre-treatment of murine cortico-hippocampal neuronal cultures with the complement derived anaphylatoxin C5a, protects against glutamate mediated apoptosis. O...

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Detalles Bibliográficos
Autores principales: Mukherjee, Piali, Thomas, Sunil, Pasinetti, Giulio Maria
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246107/
https://www.ncbi.nlm.nih.gov/pubmed/18230183
http://dx.doi.org/10.1186/1742-2094-5-5