Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies

Superagonistic CD28 antibodies (CD28SAs) activate T lymphocytes without concomitant perturbation of the TCR/CD3-complex. In rodents these reagents induce the preferential expansion of regulatory T cells and can be used for the treatment of autoimmune diseases. Unexpectedly, the humanized CD28 supera...

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Detalles Bibliográficos
Autores principales: Waibler, Zoe, Sender, Linda Y., Merten, Camilla, Hartig, Roland, Kliche, Stefanie, Gunzer, Matthias, Reichardt, Peter, Kalinke, Ulrich, Schraven, Burkhart
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246163/
https://www.ncbi.nlm.nih.gov/pubmed/18320029
http://dx.doi.org/10.1371/journal.pone.0001708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246163/
https://www.ncbi.nlm.nih.gov/pubmed/18320029
http://dx.doi.org/10.1371/journal.pone.0001708

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