Cargando…

Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies

Superagonistic CD28 antibodies (CD28SAs) activate T lymphocytes without concomitant perturbation of the TCR/CD3-complex. In rodents these reagents induce the preferential expansion of regulatory T cells and can be used for the treatment of autoimmune diseases. Unexpectedly, the humanized CD28 supera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waibler, Zoe, Sender, Linda Y., Merten, Camilla, Hartig, Roland, Kliche, Stefanie, Gunzer, Matthias, Reichardt, Peter, Kalinke, Ulrich, Schraven, Burkhart
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246163/ https://www.ncbi.nlm.nih.gov/pubmed/18320029 http://dx.doi.org/10.1371/journal.pone.0001708

Ejemplares similares

CD28 Superagonist Shock and Blockage of Motogenic T Cell Cascade
por: Sundqvist, Karl-Gösta
Publicado: (2021)

LIME: A New Membrane Raft-associated Adaptor Protein Involved in CD4 and CD8 Coreceptor Signaling
por: Brdičková, Naděžda, et al.
Publicado: (2003)

Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection
por: Kästle, Matthias, et al.
Publicado: (2022)

Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
por: Beyersdorf, Niklas, et al.
Publicado: (2005)

Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists
por: Lühder, Fred, et al.
Publicado: (2003)

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions
por: Kästle, Matthias, et al.
Publicado: (2020)

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events
por: Dadwal, Nirdosh, et al.
Publicado: (2021)

Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice
por: Gogishvili, Tea, et al.
Publicado: (2009)

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program
por: Thaventhiran, Thilipan, et al.
Publicado: (2019)

Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation
por: Langenhorst, Daniela, et al.
Publicado: (2018)

Revisiting CD28 Superagonist TGN1412 as Potential Therapeutic for Pediatric B Cell Leukemia: A Review
por: Brown, Katelyn E.
Publicado: (2018)

Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties
por: Elsayed, Abdullah, et al.
Publicado: (2023)

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling
por: Levin, Susan E., et al.
Publicado: (2008)

Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist
por: Thaventhiran, Thilipan, et al.
Publicado: (2014)

Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells
por: Que, Weitao, et al.
Publicado: (2022)

Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson’s disease mice
por: Badr, Mohammad, et al.
Publicado: (2022)

CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke
por: Schuhmann, Michael K, et al.
Publicado: (2015)

Superagonistic CD28 protects against renal ischemia injury induced fibrosis through a regulatory T-cell expansion dependent mechanism
por: Liang, Yiran, et al.
Publicado: (2019)

Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE
por: Rudolph, Jochen, et al.
Publicado: (2019)

Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
por: Harder, Thomas, et al.
Publicado: (2014)

TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model
por: Weißmüller, Sabrina, et al.
Publicado: (2016)

Are there superagonists for calcium-activated potassium channels?
por: Brown, Brandon M., et al.
Publicado: (2017)

Correction: Adhesion and Degranulation Promoting Adapter Protein (ADAP) Is a Central Hub for Phosphotyrosine-Mediated Interactions in T Cells
por: Sylvester, Marc, et al.
Publicado: (2010)

Adhesion and Degranulation Promoting Adapter Protein (ADAP) Is a Central Hub for Phosphotyrosine-Mediated Interactions in T Cells
por: Sylvester, Marc, et al.
Publicado: (2010)

Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells
por: Waldt, Natalie, et al.
Publicado: (2018)

Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells
por: Vogel, Stephanie, et al.
Publicado: (2015)

Rapid Immunomagnetic Negative Enrichment of Neutrophil Granulocytes from Murine Bone Marrow for Functional Studies In Vitro and In Vivo
por: Hasenberg, Mike, et al.
Publicado: (2011)

Anti-CD40 Antibody Fused to CD40 Ligand Is a Superagonist Platform for Adjuvant Intrinsic DC-Targeting Vaccines
por: Ceglia, Valentina, et al.
Publicado: (2022)

Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor
por: Thirunarayanan, Nanthakumar, et al.
Publicado: (2012)

New Roles for Vitamin D Superagonists: From COVID to Cancer
por: Easty, David J., et al.
Publicado: (2021)

Influenza B Virus Ribonucleoprotein Is a Potent Activator of the Antiviral Kinase PKR
por: Dauber, Bianca, et al.
Publicado: (2009)

Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer
por: Wei, Pengcheng, et al.
Publicado: (2021)

Mu-opioid receptor selective superagonists produce prolonged respiratory depression
por: Malcolm, Nicholas J., et al.
Publicado: (2023)

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
por: Schultz, Annika, et al.
Publicado: (2022)

4308 DEEP-PRIMED IL-15 SUPERAGONIST IMPROVES ANTIVIRAL EFFICACY OF HIV-SPECIFIC CD8(+) T-CELLS IN HUMANIZED MOUSE MODEL
por: McCann, Chase Daniel, et al.
Publicado: (2020)

Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
por: Knudson, Karin M., et al.
Publicado: (2019)

Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice
por: Battista, Maria Rosaria, et al.
Publicado: (2022)

Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil—Microglia interaction during stroke in vivo
por: Neumann, Jens, et al.
Publicado: (2018)

miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4(+) T Cells
por: Reddycherla, Amarendra V., et al.
Publicado: (2015)

Antitumor activity of an immunocytokine composed of an anti-GD2 antibody and the IL-15 superagonist RLI
por: Vincent, Marie, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0hbkm5ef6cnbrarhoad6lnmnbk