Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.

DBA2 mice were inoculated i.p. with 10(5)L1210 cells. Animals subsequently treated with daunomycin (single i.p. dose, 0.25-5.0 mg kg-1) all died. The maximum increase in mean survival time observed was approximately 135%. Animals treated with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers conju...

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Detalles Bibliográficos
Autores principales: Duncan, R., Kopecková, P., Strohalm, J., Hume, I. C., Lloyd, J. B., Kopecek, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246422/
https://www.ncbi.nlm.nih.gov/pubmed/3358905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246422/
https://www.ncbi.nlm.nih.gov/pubmed/3358905

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