Cargando…

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia.

DBA2 mice were inoculated i.p. with 10(5)L1210 cells. Animals subsequently treated with daunomycin (single i.p. dose, 0.25-5.0 mg kg-1) all died. The maximum increase in mean survival time observed was approximately 135%. Animals treated with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers conju...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duncan, R., KopeckovÃ¡, P., Strohalm, J., Hume, I. C., Lloyd, J. B., Kopecek, J.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1988
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246422/ https://www.ncbi.nlm.nih.gov/pubmed/3358905

Ejemplares similares

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.
por: Duncan, R., et al.
Publicado: (1987)

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat.
por: Wedge, S. R., et al.
Publicado: (1991)

N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice.
por: Seymour, L. W., et al.
Publicado: (1991)

N-(2-hydroxypropyl)methacrylamide–amphotericin B (HPMA–AmB) copolymer conjugates as antileishmanial agents
por: Nicoletti, Salvatore, et al.
Publicado: (2009)

Synthesis, Morphology, and Rheological Evaluation of HPMA (N-2-Hydroxypropyl Methacrylamide)-PCL (Polycaprolactone) Conjugates
por: Rani, Sarita, et al.
Publicado: (2021)

Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins
por: Janisova, Larisa, et al.
Publicado: (2020)

Combination Chemotherapy and Photodynamic Therapy with Fab′ Fragment Targeted HPMA Copolymer Conjugates in Human Ovarian Carcinoma Cells
por: Hongrapipat, Jarunee, et al.
Publicado: (2008)

Heparin does not modify plasma daunomycin disappearance in acute leukaemia patients.
por: Piazza, E., et al.
Publicado: (1980)

Development of cyclosporin A mediated immunity in L1210 leukaemia.
por: Slater, L. M., et al.
Publicado: (1991)

Adriamycin/cyclophosphamide and adriamycin/melphalan in advanced L1210 leukaemia.
por: Tobias, J. S., et al.
Publicado: (1975)

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe(2)O(3) nanoparticles towards human tumor cells
por: Plichta, Zdeněk, et al.
Publicado: (2018)

Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate
por: Visone, Valeria, et al.
Publicado: (2020)

Influence of the Drug Position on Bioactivity in Angiopep-2—Daunomycin Conjugates
por: Pethő, Lilla, et al.
Publicado: (2023)

Characterization of a monoclonal antibody to L1210 leukaemia.
por: Testorelli, C., et al.
Publicado: (1982)

The Anticancer Drug Daunomycin Directly Affects Gene Expression and DNA Structure
por: Nishio, Takashi, et al.
Publicado: (2023)

In vitro activity of daunomycin-anti-alphafoetoprotein conjugate on mouse hepatoma cells.
por: Belles-Isles, M., et al.
Publicado: (1980)

Reproductive toxicology. Methacrylamide.
Publicado: (1997)

L-histidinol improves the selectivity and efficacy of alkylating agents and daunomycin in mice with P388 leukaemia.
por: Warrington, R. C., et al.
Publicado: (1989)

Development of novel cyclic NGR peptide–daunomycin conjugates with dual targeting property
por: Tripodi, Andrea Angelo Pierluigi, et al.
Publicado: (2018)

Structural Characterization of Daunomycin-Peptide Conjugates by Various Tandem Mass Spectrometric Techniques
por: Borbély, Adina, et al.
Publicado: (2021)

Reduction of daunomycin toxicity by razoxane.
por: Wang, G., et al.
Publicado: (1981)

Effect of VM-26 on the haematological responses of mice to L1210 leukaemia.
por: Hacker, M., et al.
Publicado: (1980)

Influence of micrococcus, BCG and related polysaccharides on the proliferation of the L1210 leukaemia.
por: Verloes, R., et al.
Publicado: (1978)

Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
por: García-Peñas, Alberto, et al.
Publicado: (2019)

Active immunotherapy of L1210 leukaemia applied after the graft of tumour cells.
por: Mathé, G., et al.
Publicado: (1969)

HPMA Copolymer CXCR4 Antagonist Conjugates Substantially Inhibited the Migration of Prostate Cancer Cells
por: Peng, Zheng-Hong, et al.
Publicado: (2014)

The use of poly(N-[2-hydroxypropyl]-methacrylamide) hydrogel to repair a T10 spinal cord hemisection in rat: a behavioural, electrophysiological and anatomical examination
por: Pertici, Vincent, et al.
Publicado: (2013)

Successful immunotherapy with micrococcus, BCG or related polysaccharides on L1210 leukaemia after BCNU chemotherapy.
por: Verloes, R., et al.
Publicado: (1981)

DNA repeat length in chromatin from murine bone marrow and L1210 leukaemia cells.
por: Dean, S. W., et al.
Publicado: (1985)

A comparison of the Antileukaemic Effects of Recombinant Human Tumour Necrosis Factor-α and its Muteins on Leukaemia L1210 and Leukaemia P388 in Mice
por: Warzocha, K., et al.
Publicado: (1994)

Phage Display-Based Homing Peptide-Daunomycin Conjugates for Selective Drug Targeting to PANC-1 Pancreatic Cancer
por: Dókus, Levente E., et al.
Publicado: (2020)

Serotherapy of L1210 murine leukaemia--reasons for ineffectiveness of in vivo treatment by L.1 monoclonal antibody.
por: Testorelli, C., et al.
Publicado: (1983)

Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry
por: Reddi, Rambabu N., et al.
Publicado: (2021)

Synthesis, characterization and osteogenesis of phosphorylated methacrylamide chitosan hydrogels
por: Yang, Huishang, et al.
Publicado: (2018)

The influence of 2- chlorodeoxyadenosine in combination with tumour necrosis factor-α or its mutein on murine leukaemias L1210 and P388
por: Góra-Tybor, J., et al.
Publicado: (1995)

5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
por: Roobol, C., et al.
Publicado: (1984)

Internal Structure of Thermoresponsive Physically Crosslinked Nanogel of Poly[N-(2-hydroxypropyl)methacrylamide]-Block-Poly[N-(2,2-difluoroethyl)acrylamide], Prominent (19)F MRI Tracer
por: Babuka, David, et al.
Publicado: (2020)

Growth inhibition and apoptosis induced by daunomycin-conjugated triplex-forming oligonucleotides targeting the c-myc gene in prostate cancer cells
por: Napoli, Sara, et al.
Publicado: (2006)

Overcharging Effect in Electrospray Ionization Mass Spectra of Daunomycin-Tuftsin Bioconjugates
por: Pethő, Lilla, et al.
Publicado: (2019)

Growth conditions, physiological properties, and selection of optimal parameters of biodegradation of anticancer drug daunomycin in industrial effluents by Bjerkandera adusta CCBAS930
por: Korniłłowicz-Kowalska, Teresa, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3dksvcfe70ih5q9eh5tns2e7a1