Modulation in vitro and in vivo of cytotoxicity but not cellular levels of doxorubicin by the calmodulin inhibitor trifluoperazine is dependent on the level of resistance.

The role of the calmodulin inhibitor trifluoperazine (TFP) in modulating the cellular levels and cytotoxicity in vitro and antitumour effects in vivo of doxorubicin (DOX), was evaluated in progressively DOX-resistant (5- to 40-fold) sublines of B16-BL6 mouse melanoma. In parental-sensitive B16-BL6 c...

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Detalles Bibliográficos
Autores principales: Ganapathi, R., Schmidt, H., Grabowski, D., Melia, M., Ratliff, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246592/
https://www.ncbi.nlm.nih.gov/pubmed/3179186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246592/
https://www.ncbi.nlm.nih.gov/pubmed/3179186

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