Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.

In a study of DNAs from 100 breast cancer patients and 100 controls, there were no differences in the frequencies of common or rare alleles at the Harvey ras (c-Ha-ras) locus on chromosome 11. However, one Ha-ras allele was deleted from the tumour DNA in 14 of 65 informative patients. Loss of a Ha-r...

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Autores principales: Mackay, J., Elder, P. A., Porteous, D. J., Steel, C. M., Hawkins, R. A., Going, J. J., Chetty, U.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1988
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246883/
https://www.ncbi.nlm.nih.gov/pubmed/3066395
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author Mackay, J.
Elder, P. A.
Porteous, D. J.
Steel, C. M.
Hawkins, R. A.
Going, J. J.
Chetty, U.
author_facet Mackay, J.
Elder, P. A.
Porteous, D. J.
Steel, C. M.
Hawkins, R. A.
Going, J. J.
Chetty, U.
author_sort Mackay, J.
collection PubMed
description In a study of DNAs from 100 breast cancer patients and 100 controls, there were no differences in the frequencies of common or rare alleles at the Harvey ras (c-Ha-ras) locus on chromosome 11. However, one Ha-ras allele was deleted from the tumour DNA in 14 of 65 informative patients. Loss of a Ha-ras allele correlates with paucity of oestrogen receptor protein and with increased tumour size at presentation, but is not associated with microscopic evidence of lymph node invasion. The findings on Ha-ras and other informative loci are consistent with the possibility that a tumour suppressor gene involved in the early stages of breast cancer is located on the short arm of chromosome 11. IMAGES:
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spelling pubmed-22468832009-09-10 Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level. Mackay, J. Elder, P. A. Porteous, D. J. Steel, C. M. Hawkins, R. A. Going, J. J. Chetty, U. Br J Cancer Research Article In a study of DNAs from 100 breast cancer patients and 100 controls, there were no differences in the frequencies of common or rare alleles at the Harvey ras (c-Ha-ras) locus on chromosome 11. However, one Ha-ras allele was deleted from the tumour DNA in 14 of 65 informative patients. Loss of a Ha-ras allele correlates with paucity of oestrogen receptor protein and with increased tumour size at presentation, but is not associated with microscopic evidence of lymph node invasion. The findings on Ha-ras and other informative loci are consistent with the possibility that a tumour suppressor gene involved in the early stages of breast cancer is located on the short arm of chromosome 11. IMAGES: Nature Publishing Group 1988-12 /pmc/articles/PMC2246883/ /pubmed/3066395 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Mackay, J.
Elder, P. A.
Porteous, D. J.
Steel, C. M.
Hawkins, R. A.
Going, J. J.
Chetty, U.
Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
title Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
title_full Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
title_fullStr Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
title_full_unstemmed Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
title_short Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
title_sort partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246883/
https://www.ncbi.nlm.nih.gov/pubmed/3066395
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