Enhanced cytostatic activity of the sesquiterpene lactone eupatoriopicrin by glutathione depletion.

Eupatoriopicrin (EUP), a sesquiterpene lactone from Eupatorium cannabinum L., possesses cytostatic activity. This was demonstrated for FIO 26 cells in vitro with the aid of a clonogenic assay and in vivo by tumour growth delay in FIO 26 and Lewis lung tumour-bearing mice. In vitro the IC50 for 1 h e...

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Detalles Bibliográficos
Autores principales: Woerdenbag, H. J., Lemstra, W., Malingré, T. M., Konings, A. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246971/
https://www.ncbi.nlm.nih.gov/pubmed/2757925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246971/
https://www.ncbi.nlm.nih.gov/pubmed/2757925

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