Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions.

Two non-transformed human skin fibroblast strains, GM38 and 3437T, were found to be more sensitive to the bioreductive alkylating agents mitomycin C (MMC) and porfiromycin (PM) under hypoxic compared to aerobic conditions. One of these strains, 3437T, was 6-7 times more resistant to these agents und...

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Detalles Bibliográficos
Autores principales: Marshall, R. S., Paterson, M. C., Rauth, A. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247063/
https://www.ncbi.nlm.nih.gov/pubmed/2467684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247063/
https://www.ncbi.nlm.nih.gov/pubmed/2467684

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