Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.

19F-magnetic resonance spectroscopy (MRS) can be used to non-invasively monitor metabolism of 5-fluorouracil (5FU) to cytotoxic fluoronucleotides (FNuct). We investigated whether the levels of FNuct formed from 5FU and observed in vivo by MRS in the Walker carcinosarcoma predicted cytotoxicity. Fift...

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Detalles Bibliográficos
Autores principales: McSheehy, P. M., Prior, M. J., Griffiths, J. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247185/
https://www.ncbi.nlm.nih.gov/pubmed/2789936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247185/
https://www.ncbi.nlm.nih.gov/pubmed/2789936

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