A possible explanation for the peripheral selectivity of a novel non-steroidal pure antiandrogen, Casodex (ICI 176,334).

The in vivo antiandrogenicity of Casodex has been confirmed and characterised. Androgen receptor (AR) binding assays of rat ventral prostate gland cytosols revealed a relative binding affinity (RBA) for the AR of 0.267 and a k1 of 1.25 x 10(-7) M for Casodex. In addition, the peripheral selectivity...

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Detalles Bibliográficos
Autores principales: Freeman, S. N., Mainwaring, W. I., Furr, B. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1989
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247300/
https://www.ncbi.nlm.nih.gov/pubmed/2803943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2247300/
https://www.ncbi.nlm.nih.gov/pubmed/2803943

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