Inflammatory Mediators Increase Nav1.9 Current and Excitability in Nociceptors through a Coincident Detection Mechanism

Altered function of Na(+) channels is responsible for increased hyperexcitability of primary afferent neurons that may underlie pathological pain states. Recent evidence suggests that the Nav1.9 subunit is implicated in inflammatory but not acute pain. However, the contribution of Nav1.9 channels to...

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Detalles Bibliográficos
Autores principales: Maingret, François, Coste, Bertrand, Padilla, Françoise, Clerc, Nadine, Crest, Marcel, Korogod, Sergiy M., Delmas, Patrick
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248717/
https://www.ncbi.nlm.nih.gov/pubmed/18270172
http://dx.doi.org/10.1085/jgp.200709935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248717/
https://www.ncbi.nlm.nih.gov/pubmed/18270172
http://dx.doi.org/10.1085/jgp.200709935

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