Cargando…
SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy
BRCA1, a tumor suppressor gene, is implicated in the repression and activation of transcription via interactions with a diverse range of proteins. The mechanisms regulating the action of BRCA1 are not fully understood. Here, we use the promoters of Gadd45α, p27(KIP1) and p21(WAF1/CIP1) to demonstrat...
| Autores principales: | , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248730/ https://www.ncbi.nlm.nih.gov/pubmed/18025037 http://dx.doi.org/10.1093/nar/gkm969 |