Incorporation of extracellular 8-oxodG into DNA and RNA requires purine nucleoside phosphorylase in MCF-7 cells

7,8-Dihydro-8-oxo-2′-deoxyguanosine (8-oxodG) is a well-known marker of oxidative stress. We report a mechanistic analysis of several pathways by which 8-oxodG is converted to nucleotide triphosphates and incorporated into both DNA and RNA. Exposure of MCF-7 cells to [(14)C]8-oxodG combined with spe...

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Detalles Bibliográficos
Autores principales: Mundt, Janna M., Hah, Sang Soo, Sumbad, Rhoda A., Schramm, Vern, Henderson, Paul T.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248762/
https://www.ncbi.nlm.nih.gov/pubmed/18025045
http://dx.doi.org/10.1093/nar/gkm1032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248762/
https://www.ncbi.nlm.nih.gov/pubmed/18025045
http://dx.doi.org/10.1093/nar/gkm1032

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