Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

At the interface between T cell and antigen-presenting cell (APC), peptide antigen presented by MHC (pMHC) binds to the T cell receptor (TCR) and initiates signaling. The mechanism of TCR signal initiation, or triggering, remains unclear. An interesting aspect of this puzzle is that although soluble...

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Detalles Bibliográficos
Autores principales: Ma, Zhengyu, Sharp, Kim A, Janmey, Paul A, Finkel, Terri H
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253636/
https://www.ncbi.nlm.nih.gov/pubmed/18303949
http://dx.doi.org/10.1371/journal.pbio.0060043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253636/
https://www.ncbi.nlm.nih.gov/pubmed/18303949
http://dx.doi.org/10.1371/journal.pbio.0060043

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