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Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity
At the interface between T cell and antigen-presenting cell (APC), peptide antigen presented by MHC (pMHC) binds to the T cell receptor (TCR) and initiates signaling. The mechanism of TCR signal initiation, or triggering, remains unclear. An interesting aspect of this puzzle is that although soluble...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253636/ https://www.ncbi.nlm.nih.gov/pubmed/18303949 http://dx.doi.org/10.1371/journal.pbio.0060043 |