The Anti-Proliferative Effects of the CHFR Depend on the Forkhead Associated Domain, but not E3 Ligase Activity Mediated by Ring Finger Domain

The CHFR protein comprises fork head associated- (FHA) and RING-finger (RF) domain and is frequently downregulated in human colon and gastric cancers up to 50%. The loss of CHFR mRNA expression is a consequence of promoter methylation, suggesting a tumor suppressor role for this gene in gastrointest...

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Detalles Bibliográficos
Autores principales: Fukuda, Tomokazu, Kondo, Yasuyuki, Nakagama, Hitoshi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258000/
https://www.ncbi.nlm.nih.gov/pubmed/18335050
http://dx.doi.org/10.1371/journal.pone.0001776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258000/
https://www.ncbi.nlm.nih.gov/pubmed/18335050
http://dx.doi.org/10.1371/journal.pone.0001776

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