Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)

BACKGROUND: Chemotherapeutic drug efflux via the P-glycoprotein (P-gp) transporter encoded by the MDR1/ABCB1 gene is a significant cause of drug resistance in numerous malignancies, including acute leukemias, especially in older patients with acute myeloid leukemia (AML). Therefore, the P-gp modulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Ruoping, Faussat, Anne-Marie, Perrot, Jean-Yves, Marjanovic, Zora, Cohen, Simy, Storme, Thomas, Morjani, Hamid, Legrand, Ollivier, Marie, Jean-Pierre
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258302/
https://www.ncbi.nlm.nih.gov/pubmed/18271955
http://dx.doi.org/10.1186/1471-2407-8-51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258302/
https://www.ncbi.nlm.nih.gov/pubmed/18271955
http://dx.doi.org/10.1186/1471-2407-8-51

Ejemplares similares