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Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML)

BACKGROUND: Chemotherapeutic drug efflux via the P-glycoprotein (P-gp) transporter encoded by the MDR1/ABCB1 gene is a significant cause of drug resistance in numerous malignancies, including acute leukemias, especially in older patients with acute myeloid leukemia (AML). Therefore, the P-gp modulat...

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Detalles Bibliográficos
Autores principales:	Tang, Ruoping, Faussat, Anne-Marie, Perrot, Jean-Yves, Marjanovic, Zora, Cohen, Simy, Storme, Thomas, Morjani, Hamid, Legrand, Ollivier, Marie, Jean-Pierre
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258302/ https://www.ncbi.nlm.nih.gov/pubmed/18271955 http://dx.doi.org/10.1186/1471-2407-8-51

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