Targeting telomerase for cancer therapeutics

One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeut...

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Detalles Bibliográficos
Autores principales: Shay, J W, Keith, W N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259186/
https://www.ncbi.nlm.nih.gov/pubmed/18231105
http://dx.doi.org/10.1038/sj.bjc.6604209
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author Shay, J W
Keith, W N
author_facet Shay, J W
Keith, W N
author_sort Shay, J W
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description One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.
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spelling pubmed-22591862009-09-10 Targeting telomerase for cancer therapeutics Shay, J W Keith, W N Br J Cancer Minireview One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells. Nature Publishing Group 2008-02-26 2008-01-29 /pmc/articles/PMC2259186/ /pubmed/18231105 http://dx.doi.org/10.1038/sj.bjc.6604209 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Shay, J W
Keith, W N
Targeting telomerase for cancer therapeutics
title Targeting telomerase for cancer therapeutics
title_full Targeting telomerase for cancer therapeutics
title_fullStr Targeting telomerase for cancer therapeutics
title_full_unstemmed Targeting telomerase for cancer therapeutics
title_short Targeting telomerase for cancer therapeutics
title_sort targeting telomerase for cancer therapeutics
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259186/
https://www.ncbi.nlm.nih.gov/pubmed/18231105
http://dx.doi.org/10.1038/sj.bjc.6604209
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