Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction

BACKGROUND: The hepatitis C virus (HCV) non-structural 5A protein (NS5A) contains a highly conserved C-terminal polyproline motif with the consensus sequence Pro-X-X-Pro-X-Arg that is able to interact with the Src-homology 3 (SH3) domains of a variety of cellular proteins. RESULTS: To understand thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Shelton, Holly, Harris, Mark
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259325/
https://www.ncbi.nlm.nih.gov/pubmed/18267011
http://dx.doi.org/10.1186/1743-422X-5-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259325/
https://www.ncbi.nlm.nih.gov/pubmed/18267011
http://dx.doi.org/10.1186/1743-422X-5-24

Ejemplares similares