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Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response
Heat shock proteins (hsps) are protective against the harmful effects of mutant expanded polyglutamine repeat proteins that occur in diseases such as Huntington’s, prompting the search for pharmacologic compounds that increase hsp expression in cells as potential treatments for this and related dise...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262918/ https://www.ncbi.nlm.nih.gov/pubmed/17943263 http://dx.doi.org/10.1007/s00109-007-0251-9 |