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Proteasome activator PA28γ regulates p53 by enhancing its MDM2-mediated degradation
Downregulation of p53 by MDM2-mediated proteasomal degradation makes cells resistant to apoptosis. The MDM2–p53 interaction is well characterized, but the mechanisms that regulate the interaction are not well understood. Here, we show that PA28γ, a proteasome activator that inhibits apoptosis and pr...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265109/ https://www.ncbi.nlm.nih.gov/pubmed/18309296 http://dx.doi.org/10.1038/emboj.2008.25 |