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Negative Feedback Regulation of T Cells via Interleukin-2 and FOXP3 Reciprocity
As interleukin-2 (IL2) is central to the clonal expansion of antigen-selected T cells, we investigated the relationship between IL2 and the negative regulatory transcription factor FOXP3. We found IL2 to be responsible for T cell antigen receptor (TCR)-activated FOXP3 expression by both CD4+ and CD8...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265256/ https://www.ncbi.nlm.nih.gov/pubmed/18324310 http://dx.doi.org/10.1371/journal.pone.0001581 |