Cargando…

Negative Feedback Regulation of T Cells via Interleukin-2 and FOXP3 Reciprocity

As interleukin-2 (IL2) is central to the clonal expansion of antigen-selected T cells, we investigated the relationship between IL2 and the negative regulatory transcription factor FOXP3. We found IL2 to be responsible for T cell antigen receptor (TCR)-activated FOXP3 expression by both CD4+ and CD8...

Descripción completa

Detalles Bibliográficos
Autores principales:	Popmihajlov, Zoran, Smith, Kendall A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265256/ https://www.ncbi.nlm.nih.gov/pubmed/18324310 http://dx.doi.org/10.1371/journal.pone.0001581

Ejemplares similares

Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation
por: Popmihajlov, Zoran, et al.
Publicado: (2012)

Immunotherapy with Canarypox Vaccine and Interleukin-2 for HIV-1 Infection: Termination of a Randomized Trial
por: Smith, Kendall A, et al.
Publicado: (2007)

A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3(+) T(REG) differentiation
por: Mamontov, Polina, et al.
Publicado: (2019)

Interleukin 4 inhibits TGF-β-induced-Foxp3(+)T cells and generates, in combination with TGF-β, Foxp3(−) effector T cells that produce interleukins 9 and 10
por: Dardalhon, Valérie, et al.
Publicado: (2008)

Individuals reciprocate negative actions revealing negative upstream reciprocity
por: Umetani, Ryohei, et al.
Publicado: (2023)

Reciprocal modulation of 5-HT and octopamine regulates pumping via feedforward and feedback circuits in C. elegans
por: Liu, Hui, et al.
Publicado: (2019)

Interleukin-7 Optimizes FOXP3+CD4+ Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression
por: Simonetta, Federico, et al.
Publicado: (2014)

You Have My Word: Reciprocity Expectation Modulates Feedback-Related Negativity in the Trust Game
por: Ma, Qingguo, et al.
Publicado: (2015)

Interleukin-7 Influences FOXP3(+)CD4(+) Regulatory T Cells Peripheral Homeostasis
por: Simonetta, Federico, et al.
Publicado: (2012)

Premature Expression of Foxp3 in Double-Negative Thymocytes
por: Barra, Melanie M., et al.
Publicado: (2015)

Identification of a reciprocal negative feedback loop between tau-modifying proteins MARK2 kinase and CBP acetyltransferase
por: Tabassum, Zarin, et al.
Publicado: (2022)

Foxp3-Positive Regulatory T Cells Contribute to Antifibrotic Effects in Renal Fibrosis via an Interleukin-18 Receptor Signaling Pathway
por: Hirooka, Yasuaki, et al.
Publicado: (2020)

Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells
por: Delacher, Michael, et al.
Publicado: (2020)

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
por: Pelly, Victoria S., et al.
Publicado: (2017)

IdentifICATION OF E3 ubiquitin ligase STUB1 as a negative regulator of FOXP3
por: Chen, ZJ, et al.
Publicado: (2011)

Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis
por: Singh, Narendra P., et al.
Publicado: (2011)

Interleukin-2/antibody complex expanding Foxp3+ regulatory T cells exacerbates Th2-mediated allergic airway inflammation
por: Hong, Sung-Wook, et al.
Publicado: (2019)

FOXP3 expression in FOXP3(+) tumor cells promotes hepatocellular cells metastasis
por: Zhang, Henghui, et al.
Publicado: (2020)

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3(+) and Foxp3(−) T cells
por: Franckaert, Dean, et al.
Publicado: (2015)

Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells
por: Kannappan, Vinodh, et al.
Publicado: (2017)

Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells
por: Hench, Virginia K, et al.
Publicado: (2011)

DNA array analysis of interleukin-2-regulated immediate/early genes
por: Beadling, Carol, et al.
Publicado: (2002)

Association between Intratumoral CD8+ T Cells with FoxP3+ and CD163+ Cells: A Potential Immune Intrinsic Negative Feedback Mechanism for Acquired Immune Resistance
por: Fortis, Sotirios P., et al.
Publicado: (2022)

Runx proteins regulate Foxp3 expression
por: Bruno, Ludovica, et al.
Publicado: (2009)

Reciprocal regulation of interleukin-17A and interleukin-22 secretion through aryl hydrocarbon receptor activation in CD4(+) T cells of patients with vitiligo
por: Liu, Baoyi, et al.
Publicado: (2021)

Apes reciprocate food positively and negatively
por: Benozio, Avi, et al.
Publicado: (2023)

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
por: Tape, Christopher J., et al.
Publicado: (2016)

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
por: Tape, Christopher J., et al.
Publicado: (2016)

Human and Mouse CD8(+)CD25(+)FOXP3(+) Regulatory T Cells at Steady State and during Interleukin-2 Therapy
por: Churlaud, Guillaume, et al.
Publicado: (2015)

Foxp1 regulation of neonatal vocalizations via cortical development
por: Usui, Noriyoshi, et al.
Publicado: (2017)

Expression of Foxp3 and interleukin-7 receptor and clinicopathological characteristics of patients with diffuse large B-cell lymphoma
por: Zhao, Yan, et al.
Publicado: (2020)

Association between interleukin-10 polymorphisms and CD4(+)CD25(+)FOXP3(+) T cells in asthmatic children
por: Mocellin, Magáli, et al.
Publicado: (2021)

Distinct Roles for FOXP3(+) and FOXP3(−) CD4(+) T Cells in Regulating Cellular Immunity to Uncomplicated and Severe Plasmodium falciparum Malaria
por: Walther, Michael, et al.
Publicado: (2009)

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3
por: Ohteki, Toshiaki, et al.
Publicado: (2000)

Reciprocal regulation of glycine-rich RNA-binding proteins via an interlocked feedback loop coupling alternative splicing to nonsense-mediated decay in Arabidopsis
por: Schöning, Jan C., et al.
Publicado: (2008)

KLF4 functions as an activator of the androgen receptor through reciprocal feedback
por: Siu, M-K, et al.
Publicado: (2016)

Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy
por: Li, Yanan, et al.
Publicado: (2019)

Negative regulation of interleukin 2 transcription by the glucocorticoid receptor
Publicado: (1992)

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging
por: Wang, Rui-Hong, et al.
Publicado: (2016)

Commentary: The Interleukin-2 T Cell System: A New Cell Growth Model
por: Smith, Kendall Arthur
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_u9q8goq5041i57i6ub6dtf4rpi