Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-X(L )and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL). This prompted us to evaluate a very potent non-peptidic Small-Molecule Inhibitor (SMI) targeting Bcl-2 family proteins, Apogossypolone (ApoG2) using follicu...

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Detalles Bibliográficos
Autores principales: Arnold, Alan A, Aboukameel, Amro, Chen, Jianyong, Yang, Dajun, Wang, Shaomeng, Al-Katib, Ayad, Mohammad, Ramzi M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265299/
https://www.ncbi.nlm.nih.gov/pubmed/18275607
http://dx.doi.org/10.1186/1476-4598-7-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265299/
https://www.ncbi.nlm.nih.gov/pubmed/18275607
http://dx.doi.org/10.1186/1476-4598-7-20

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