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Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-X(L )and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model

Elevated expression of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL). This prompted us to evaluate a very potent non-peptidic Small-Molecule Inhibitor (SMI) targeting Bcl-2 family proteins, Apogossypolone (ApoG2) using follicu...

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Detalles Bibliográficos
Autores principales:	Arnold, Alan A, Aboukameel, Amro, Chen, Jianyong, Yang, Dajun, Wang, Shaomeng, Al-Katib, Ayad, Mohammad, Ramzi M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265299/ https://www.ncbi.nlm.nih.gov/pubmed/18275607 http://dx.doi.org/10.1186/1476-4598-7-20

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