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DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore
The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase cascades, and inhibits the cell cycle. The SAC relies on kinetochore-dependent assembl...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265443/ https://www.ncbi.nlm.nih.gov/pubmed/18454191 http://dx.doi.org/10.1371/journal.pgen.1000015 |