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DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore

The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase cascades, and inhibits the cell cycle. The SAC relies on kinetochore-dependent assembl...

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Detalles Bibliográficos
Autores principales:	Kim, Eun Mi, Burke, Daniel J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265443/ https://www.ncbi.nlm.nih.gov/pubmed/18454191 http://dx.doi.org/10.1371/journal.pgen.1000015

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