Cargando…

DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore

The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase cascades, and inhibits the cell cycle. The SAC relies on kinetochore-dependent assembl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Eun Mi, Burke, Daniel J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265443/ https://www.ncbi.nlm.nih.gov/pubmed/18454191 http://dx.doi.org/10.1371/journal.pgen.1000015

Ejemplares similares

DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes
por: Lane, Simon I. R., et al.
Publicado: (2017)

A kinetochore-based ATM/ATR-independent DNA damage checkpoint maintains genomic integrity in trypanosomes
por: Zhou, Qing, et al.
Publicado: (2019)

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response
por: Lin, Yunfeng, et al.
Publicado: (2023)

Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair
por: Joyce, Eric F., et al.
Publicado: (2011)

The Importance of ATM and ATR in Physcomitrella patens DNA Damage Repair, Development, and Gene Targeting
por: Martens, Martin, et al.
Publicado: (2020)

Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection
por: Jiang, Mengxi, et al.
Publicado: (2012)

CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage
por: Vadnais, Charles, et al.
Publicado: (2012)

Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors
por: Grimley, Edward, et al.
Publicado: (2021)

Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner
por: Grabowska, Wioleta, et al.
Publicado: (2015)

ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle
por: Ray, Alo, et al.
Publicado: (2016)

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma: ATM, ATR and FA in lung carcinoma
por: Beumer, Jan H., et al.
Publicado: (2015)

ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage
por: Kostyusheva, Anastasiya, et al.
Publicado: (2019)

Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells
por: Takeuchi, Makoto, et al.
Publicado: (2019)

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway
por: Rizzo, Angela, et al.
Publicado: (2009)

Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism
por: Burger, Kaspar, et al.
Publicado: (2019)

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions
por: Soni, Aashish, et al.
Publicado: (2022)

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair
por: Lima, Michelle, et al.
Publicado: (2016)

Inactivation of ATM/ATR DNA Damage Checkpoint Promotes Androgen Induced Chromosomal Instability in Prostate Epithelial Cells
por: Chiu, Yung-Tuen, et al.
Publicado: (2012)

Bub1 regulates chromosome segregation in a kinetochore-independent manner
por: Klebig, Christiane, et al.
Publicado: (2009)

ATM regulates ATR chromatin loading in response to DNA double-strand breaks
por: Cuadrado, Myriam, et al.
Publicado: (2006)

"ATR activation in response to ionizing radiation: still ATM territory"
por: Cuadrado, Myriam, et al.
Publicado: (2006)

Quantitative Phosphoproteomics of the Ataxia Telangiectasia-Mutated (ATM) and Ataxia Telangiectasia-Mutated and Rad3-related (ATR) Dependent DNA Damage Response in Arabidopsis thaliana
por: Roitinger, Elisabeth, et al.
Publicado: (2015)

Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage
por: da Silva, Raíssa Bernardes, et al.
Publicado: (2018)

β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage
por: Snow, Jazmine A., et al.
Publicado: (2019)

Regulation of ATR-dependent DNA damage response by nitric oxide
por: Yeo, Chay Teng, et al.
Publicado: (2021)

JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway
por: Khashab, Farah, et al.
Publicado: (2021)

Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR
por: Wang, Fangfang, et al.
Publicado: (2022)

ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
por: Menolfi, Demis, et al.
Publicado: (2020)

High Fidelity Deep Sequencing Reveals No Effect of ATM, ATR, and DNA-PK Cellular DNA Damage Response Pathways on Adenovirus Mutation Rate
por: Risso-Ballester, Jennifer, et al.
Publicado: (2019)

ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response
por: Vega-Muñoz, Isaac, et al.
Publicado: (2023)

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
por: Guerra, Lina, et al.
Publicado: (2010)

The Activation Of ATM Depends On Chromatin Interactions Occurring Prior To DNA-Damage Induction
por: Kim, Yong-Chul, et al.
Publicado: (2008)

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G(2)-checkpoint in S-phase irradiated cells
por: Mladenov, Emil, et al.
Publicado: (2019)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers
por: Abdel-Fatah, Tarek M.A., et al.
Publicado: (2014)

Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G(2)-phase
por: Mladenov, Emil, et al.
Publicado: (2019)

Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner
por: Guo, Jiajie, et al.
Publicado: (2014)

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response
por: Karlseder, Jan, et al.
Publicado: (2004)

PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma
por: Liu, Chunying, et al.
Publicado: (2021)

eIF3a‐PPP2R5A‐mediated ATM/ATR dephosphorylation is essential for irinotecan‐induced DNA damage response
por: Mei, Chao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j7k7v67uedp0i1qvroemvvevi1