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SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
Expansion of the CGG•CCG-repeat tract in the 5′ UTR of the FMR1 gene to >200 repeats leads to heterochromatinization of the promoter and gene silencing. This results in Fragile X syndrome (FXS), the most common heritable form of mental retardation. The mechanism of gene silencing is unknown. We r...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265469/ https://www.ncbi.nlm.nih.gov/pubmed/18369442 http://dx.doi.org/10.1371/journal.pgen.1000017 |