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How Protein Stability and New Functions Trade Off

Numerous studies have noted that the evolution of new enzymatic specificities is accompanied by loss of the protein's thermodynamic stability (ΔΔG), thus suggesting a tradeoff between the acquisition of new enzymatic functions and stability. However, since most mutations are destabilizing (ΔΔG&...

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Detalles Bibliográficos
Autores principales: Tokuriki, Nobuhiko, Stricher, Francois, Serrano, Luis, Tawfik, Dan S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265470/
https://www.ncbi.nlm.nih.gov/pubmed/18463696
http://dx.doi.org/10.1371/journal.pcbi.1000002