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Nuclear polyglutamine-containing protein aggregates as active proteolytic centers

Protein aggregates and nuclear inclusions (NIs) containing components of the ubiquitin–proteasome system (UPS), expanded polyglutamine (polyQ) proteins, and transcriptional coactivators characterize cellular responses to stress and are hallmarks of neurodegenerative diseases. The biological function...

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Detalles Bibliográficos
Autores principales: Chen, Min, Singer, Lena, Scharf, Andrea, von Mikecz, Anna
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265588/
https://www.ncbi.nlm.nih.gov/pubmed/18283109
http://dx.doi.org/10.1083/jcb.200708131