Cargando…

Nuclear polyglutamine-containing protein aggregates as active proteolytic centers

Protein aggregates and nuclear inclusions (NIs) containing components of the ubiquitin–proteasome system (UPS), expanded polyglutamine (polyQ) proteins, and transcriptional coactivators characterize cellular responses to stress and are hallmarks of neurodegenerative diseases. The biological function...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Min, Singer, Lena, Scharf, Andrea, von Mikecz, Anna
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2008
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265588/ https://www.ncbi.nlm.nih.gov/pubmed/18283109 http://dx.doi.org/10.1083/jcb.200708131

Ejemplares similares

Recruitment and the Role of Nuclear Localization in Polyglutamine-mediated Aggregation
por: Perez, Matthew K., et al.
Publicado: (1998)

Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation
por: Howard, Rebecca A, et al.
Publicado: (2007)

Nuclear accumulation of polyglutamine disease proteins and neuropathology
por: Havel, Lauren S, et al.
Publicado: (2009)

The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli
por: Invernizzi, Gaetano, et al.
Publicado: (2012)

Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates
por: Wear, Maggie P., et al.
Publicado: (2015)

Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases
por: Takeuchi, Toshihide, et al.
Publicado: (2017)

Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases
por: Minakawa, Eiko N., et al.
Publicado: (2021)

Pathology and function of nuclear amyloid: Protein homeostasis matters
por: von Mikecz, Anna
Publicado: (2014)

Molecular Origin of Polyglutamine Aggregation in Neurodegenerative Diseases
por: Khare, Sagar D, et al.
Publicado: (2005)

Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity
por: Leach, Michelle D., et al.
Publicado: (2016)

Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch
por: Kuiper, E. F. E., et al.
Publicado: (2017)

Formation and persistence of polyglutamine aggregates in mistranslating cells
por: Lant, Jeremy T, et al.
Publicado: (2021)

Conformational Targeting of Fibrillar Polyglutamine Proteins in Live Cells Escalates Aggregation and Cytotoxicity
por: Kvam, Erik, et al.
Publicado: (2009)

The Ginkgo biloba Extract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation
por: Stark, Marcel, et al.
Publicado: (2014)

Identities of Sequestered Proteins in Aggregates from Cells with Induced Polyglutamine Expression
por: Suhr, Steven T., et al.
Publicado: (2001)

Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases
por: von Mikecz, Anna, et al.
Publicado: (2020)

Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans
por: Kim, Dong-Kyu, et al.
Publicado: (2017)

Molecular dynamics analysis of the aggregation propensity of polyglutamine segments
por: Wen, Jingran, et al.
Publicado: (2017)

Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?
por: Marcelo, Adriana, et al.
Publicado: (2021)

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
por: Kandola, Tej, et al.
Publicado: (2023)

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
por: Kandola, Tej, et al.
Publicado: (2023)

The Mechanisms of Nuclear Proteotoxicity in Polyglutamine Spinocerebellar Ataxias
por: Lee, Davin, et al.
Publicado: (2020)

Prion Formation and Polyglutamine Aggregation Are Controlled by Two Classes of Genes
por: Manogaran, Anita L., et al.
Publicado: (2011)

Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases
por: Sugaya, Keizo, et al.
Publicado: (2009)

Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans
por: Skibinski, Gregory A, et al.
Publicado: (2012)

A discontinuous Galerkin model for fluorescence loss in photobleaching of intracellular polyglutamine protein aggregates
por: Hansen, Christian V., et al.
Publicado: (2018)

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation
por: Teuling, Eva, et al.
Publicado: (2011)

FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation
por: Furtado, Gabriel Vasata, et al.
Publicado: (2021)

An Amyloidogenic Sequence at the N-Terminus of the Androgen Receptor Impacts Polyglutamine Aggregation
por: Oppong, Emmanuel, et al.
Publicado: (2017)

A homogeneous dataset of polyglutamine and glutamine rich aggregating peptides simulations
por: Barrera, Exequiel E., et al.
Publicado: (2021)

Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction
por: Pelassa, Ilaria, et al.
Publicado: (2014)

CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins
por: Zurawel, Ashley A., et al.
Publicado: (2016)

Intracellular Aggregation of Polypeptides with Expanded Polyglutamine Domain Is Stimulated by Stress-Activated Kinase Mekk1
por: Meriin, Anatoli B., et al.
Publicado: (2001)

PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins
por: Janer, Alexandre, et al.
Publicado: (2006)

Polyglutamine Expansion Accelerates the Dynamics of Ataxin-1 and Does Not Result in Aggregate Formation
por: Krol, Hilde A., et al.
Publicado: (2008)

Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response
por: Zhang, Yu-Qian, et al.
Publicado: (2007)

Critical nucleus size for disease-related polyglutamine aggregation is repeat length dependent
por: Kar, Karunakar, et al.
Publicado: (2011)

An Efficient Kinetic Model for Assemblies of Amyloid Fibrils and Its Application to Polyglutamine Aggregation
por: Prigent, Stéphanie, et al.
Publicado: (2012)

Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect
por: Sun, Chia-Sui, et al.
Publicado: (2015)

FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice
por: Kino, Yoshihiro, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qlv3kldpsrnhf0k6d3kefsn3l5