Mutations of Different Molecular Origins Exhibit Contrasting Patterns of Regional Substitution Rate Variation

Transitions at CpG dinucleotides, referred to as “CpG substitutions”, are a major mutational input into vertebrate genomes and a leading cause of human genetic disease. The prevalence of CpG substitutions is due to their mutational origin, which is dependent on DNA methylation. In comparison, other...

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Detalles Bibliográficos
Autores principales: Elango, Navin, Kim, Seong-Ho, Vigoda, Eric, Yi, Soojin V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265638/
https://www.ncbi.nlm.nih.gov/pubmed/18463707
http://dx.doi.org/10.1371/journal.pcbi.1000015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265638/
https://www.ncbi.nlm.nih.gov/pubmed/18463707
http://dx.doi.org/10.1371/journal.pcbi.1000015

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